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Mediterranean Diet Cuts Dementia Risk by 35% in High-Risk Individuals. A new study has found that closely following a Mediterranean diet can reduce the risk of dementia by at least 35% in people with two copies of the APOE4 gene, a key risk factor for Alzheimer’s. Researchers tracked more than 5,700 participants over 34 years, discovering that a diet rich in vegetables, fruits, nuts, whole grains, legumes, fish, and olive oil and low in alcohol, red, and processed meats—significantly lowered the likelihood of developing dementia. The protective effect was strongest in those carrying the APOE4 gene, especially individuals with two copies with even greater risk reduction seen among those who adhered more strictly to the diet. Scientists suggest this may be due to the way APOE4 carriers’ metabolism responds to healthy nutrients, supporting energy production, nerve repair, and overall brain function. Lead author Yuxi Liu from Harvard Medical School says improving metabolic health through diet could explain the dramatic fall in dementia risk, though further studies are needed to confirm these findings.
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