PREVIEW

Triple Therapy Wipes Out Pancreatic Tumours in Mice, Spanish Study Finds. Scientists in Spain report a major breakthrough after successfully eliminating pancreatic tumours in mice using a triple-combination treatment. The research, led by the Spanish National Cancer Research Centre, targets pancreatic ductal adenocarcinoma, one of the deadliest forms of cancer. Pancreatic cancer is notoriously difficult to treat due to its ability to rapidly develop resistance to single-drug therapies. The new approach blocks the KRAS oncogene pathway at three critical points simultaneously, preventing tumours from adapting and returning. Researchers combined an experimental KRAS inhibitor, an already approved lung cancer drug, and a protein degrader. Across three different animal models, tumours disappeared and did not recur, with no significant side effects observed. The findings were published in the scientific journal Proceedings of the National Academy of Sciences. In Spain alone, more than 10,000 people are diagnosed with pancreatic cancer each year, and fewer than one in ten survive five years after diagnosis. While the results are promising, the researchers stress that the therapy is not yet ready for human trials. They believe the study lays crucial groundwork for future clinical trials and new treatment strategies for patients.
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